87. Tuning the Drug Multimodal Release through a Co-Assembly Strategy based on Magnetic Gels

Sergio R. S. Veloso, Ecem Tiryaki, Carlos Spuch, Loic Hilliou, C. O. Amorim, V. S. Amaral, Paulo J. G. Coutinho, Paula M. T. Ferreira, Verónica Salgueiriño, Miguel A. Correa-Duarte and Elisabete M. S. Castanheira

Nanoscale (2022), in press (DOI: 10.1039/d1nr08158f).

Self-assembled short peptide-based gels as drug delivery systems require the implementation of a stimulus to modulate the release of doxorubicin, through the interplay of (di)phenylalanine-coated magnetic nanoparticles, PEGylated liposomes and the doxorubicin co-assembly.

The integration of the liposomes as doxorubicin storage units and of magnetic nanoparticles within the gel matrix enable the tuneability of both passive and active doxorubicin release through a thermal, low-frequency alternating magnetic field-based trigger.

 52 Nanoscale

86. Tuning the Thermal Properties of Aqueous Nanofluids by Taking Advantage of Size-customized Clusters of Iron Oxide Nanoparticles

Amir Elsaidy, Javier P. Vallejo, Verónica Salgueiriño and Luis Lugo

Journal of Molecular Liquids (2021), 344, 117727 (DOI: 10.1016/j.molliq.2021.117727).

The thermal conductivity of aqueous nanofluids containing clusters of iron oxide (Fe3O4 / γ-Fe2O3) nanoparticles has been investigated experimentally, with the aim of assessing the role of a controlled aggregation of nanoparticles in these final nanofluids. The clusters of nanoparticles were synthesized by a solvothermal method and fully characterized by TEM, XRD and Raman spectroscopy. The rheological behavior of the optimal nanofluids was studied by rotational rheometry, revealing enhancements in the thermal conductivity, temperature and cluster size dependent.

51 JMolLiq 

85. Manganese Ferrite Nanoparticles Encapsulated into Vitamin E/Sphingomyelin Nanoemulsions as Contrast Agents for High-Sensitive Magnetic Resonance Imaging

Sandra Díez-Villares, Miguel A. Ramos-Docampo, Andrés da Silva-Candal, Pablo Hervella, Abi J. Vázquez-Ríos, Ana B. Dávila-Ibáñez, Rafael López-López, Ramón Iglesias-Rey, Verónica Salgueiriño and María de la Fuente

Advanced Healthcare Materials (2021), 2101019 (DOI: 10.1002/adhm.202101019).

Magnetic resonance imaging (MRI) is one of the most powerful non-invasive imaging modalities used in clinics due to its great spatial resolution and excellent soft-tissue contrast, though still less sensitive than other techniques such as the nuclear imaging modalities. This lack of sensitivity can be considerably improved with the use of contrast agents based on nanomaterials. In recent years, researchers have focused on the development of magnetic nanoparticles, given their role as enhancers of the contrast signal based on the magnetic resonance. Manganese ferrite nanoparticles stand out, given their high magnetic susceptibility and magnetic soft nature. Herein, 10 nm MnFe2O4 nanoparticles, functionalized with the natural antioxidant vitamin E (VitE-MFO) are encapsulated into simple, biodegradable and non-toxic nanoemulsions (NEs), by a reproducible one-step method obtaining stable 150 nm-sized magnetic nanoemulsions (VitE-MFO-NEs). After encapsulation, the superparamagnetic properties of VitE-MFO are maintained and MR imaging studies reveal an extremely high transverse relaxivity for VitE-MFO-NEs (652.9 mM−1s−1), 2-fold higher than VitE-MFO value. Moreover, VitE-MFO-NEs show great in vivo biocompatibility and good signal at a low dose by in vivo and ex vivo MRI, which indicates their great potential for biomedical imaging enhancing the negative MR contrast and significantly improving the sensitivity of MRI.

50 2021 AHM 

84. Tunable Polarization and Surface Relief Holographic Gratings in Azopolymer Nanocomposites with Incorporated Goethite (α-FeOOH) Nanorods

L. Nedelchev, G. Mateev, V. Strijkova, V. Salgueiriño, D. S. Schmool, N. Berberova-Buhova, E. Stoykova, D. Nazarova

Photonics (2021), 8, 306 (DOI: 10.3390/photonics8080306).

Two approaches are employed to tune the properties of concurrently inscribed volumen polarization and surface relief gratings in nanocomposite thin films containing an azopolymer and goethite (α-FeOOH) nanorods.

 49 2021 photonics

83. One-pot Synthesis of TiO2/Sb2S3/RGO Complex Multicomponent Heterostructures for highly enhanced Photoelectrochemical Water Splitting

M. H. Elbakkay, W. M. A. El Rouby, A. Mariño-López, A. Sousa-Castillo, V. Salgueiriño, S. I. El-Dek, A. A. Farghali, M. A. Correa-Duarte, P. Millet

International Journal of Hydrogen Energy (2021), 46, 31216-31227 (DOI: 10.1016/j.ijhydene.2021.07.012).

The development of new sources of renewable energy fuels like hydrogen remains challenging considering the nowadays society energy needs on a day-to-day basis. In this context, hybrid nanostructures conformed by TiO2 nanoparticles sensitized with bundles of rod-like Sb2S3 (stibnite) on the surface of reduced graphene oxide (TiO2/Sb2S3/RGO), can pave the way in this direction, as offering heterostructures that can be employed as the active phase in photo-anodes for photoelectrochemical water oxidation. For that, these TiO2/Sb2S3/RGO heterostructures are able to extend the light absorption to the visible range, enhance the charge separation and transportation, and improve the conductivity of the catalyst. Furthermore, the method of synthesis, though simple, implies a one-pot strategy by which the TiO2 nanoparticles and the Sb2S3 rod-like particles are independently produced at the surface of RGO sheets, warranties the proper improved function of the hybrids and offers the engineering of future chalcogenide-based catalysts with promising water splitting photoelectrochemical properties.

48 2021 IntJHEnergy new