74. Microswimmers with Heat Delivery Capacity for 3D Cell Spheroid Penetration

Miguel A. Ramos-Docampo, Marina Fernández-Medina, Essi Taipaleenmäki, Ondrej Hovorka, Verónica Salgueiriño and Brigitte Städler

ACS Nano (2019), 13, 12192-12205 (DOI: 10.1021/acsnano.9b06869).

We report microswimmers that employ collagen, a major extracellular matrix constituent, as fuel and that have the ability to deliver heat via incorporated magnetic nanoparticles when exposed to an alternating magnetic field. Their assembly and heating properties are outlined followed by the assessment of their calcium-triggered mobility in aqueous solution and collagen gels. Furthermore, the successful penetration of the swimmers into 3D cell spheroids upon exposure to the alternating magnetic field implies that the cell viability becomes impared due to the locally delivery heat. 

 39 2019 ACS Nano